• 1,2-Dehydrogeissoschizoline, alkaloids, Apocynaceae (family), apogeissoschizine, baillon, bergibita, beta-carboline alkaloid, flavopereirene, flavopereirine, geissoschizoline, geissoschizoline N4-oxide (2), geissospermine, Geissospermum laeve, Geissospermum sericeum,Geissospermum velosii, indole alkaloids, Irlbachia alata, PB-100, pereirene, pereirine, vellosine.

• Pao pereira is an extract of the bark of the Amazonian tree Geissospermum vellosii.
• Pao pereira is commonly given together with other herbal remedies, including ginkgo (Ginkgo biloba) and the indole alkaloid alstonine. In Brazil, pao pereira is used to treat fever. South American Indian tribes have used pao pereira bark for stimulation of the immune system.
• Pao pereira contains the alkaloid flavopereirine (also called PB-100). Research suggests that flavopereirine may be active against Plasmodium falciparum, one of the parasites that causes malaria. Flavopereirine may also be useful for the treatment of cancer and viral infections. However, clinical studies in support of pao pereira for any medical condition are lacking in humans.

• Anticarcinogenic, anti-malarial, antiviral, fever, hepatitis (hepatitis C), herpes, HIV/AIDS, immune stimulation, prostate cancer (treatment/prevention).

Adults (18 years and older)

• There is no proven safe or effective dose for pao pereira in adults.

Children (under 18 years old)

• There is no proven safe or effective dose for pao pereira in children.

Allergies

• Avoid with known allergy or hypersensitivity to pao pereira, its constituents, or other members of the Apocynaceae family.

Side Effects and Warnings

• Scientific evidence is lacking on side effects associated with pao pereira.
• Although this has not been well studied in humans, high levels of pereirine, a compound found in of pao pereira, may cause paralysis, hyperthermia, and death.
• Avoid with known allergy or hypersensitivity to pao pereira, its constituents, or other members of the Apocynaceae family.

Pregnancy and Breastfeeding

• Avoid in pregnant or breastfeeding women, due to a lack of available scientific evidence.

Interactions with Drugs

• Pao pereira may interact with anticancer drugs and antimalarial agents.

Interactions with Herbs and Dietary Supplements

• Pao pereira may interact with anticancer herbs and supplements and antimalarial herbs and supplements.

• This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

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